Why would Jay respond? I'm not saying The Game isn't worthy of a reply. I'm just saying this is a bit much. For him to come out and say this kind of stuff is essentially, him saying:
"Hey, I'm a fan. I want to beef. Nothing that I say actually means anything but I will say a lot of dumb things. Please, pay attention and throw a shot. Even if you don't, I get pub, so thanks!"
No need for that. The Game isn't the best, but he is definitely a good rapper, who has had major success. I see no real reason to straight act a fool to get one man to respond. Dissing Beyonce isn't woah. No points for that one.